Playhop
Alchemist's Shop: Rune Defense

Alchemist's Shop: Rune Defense

ArcadeStrategy
NicoNicoLayy
12+

Similar games

Prison Ball
Prison Ball
Zuma's Revenge! Original
Zuma's Revenge! Original
Capy link
Capy link
XO Tactics
XO Tactics
Pop Bubbles: Find All Treasures
Pop Bubbles: Find All Treasures
Monsters & Lantern
Monsters & Lantern
Cuberra: Build & Survive
Cuberra: Build & Survive
Block Lab10
Block Lab
Obby: Chicken Farm
Obby: Chicken Farm
Prism Match 3
Prism Match 3
Fruit Room
Fruit Room
Echo Garden
Echo Garden
© 2022—2026.  Playhop
  • User agreement
  • Privacy policy
  • Digital Services Act
Technical SupportTechnical Support
Alchemist's Shop: Rune Defense

Alchemist's Shop: Rune Defense

12+
  • NicoNicoLayy
  • ·
  • Arcade
  • Strategy
Log in with your username to reliably save your game progress and achievements

About game

Protect your alchemist's shop from monster attacks! Alchemist's Shop: Rune Defense combines fantasy tower defense with roguelike enhancements and survival tactics. Construct your defenses and actively participate in the battle by precisely aiming and hurling alchemical vials. Position towers on rune locations, invest gold in improvements, and select cards between waves. Mix elements to provoke alchemical reactions and discover potent combinations to defeat slimes, rats, and heavily armored foes. When the enemy approaches, activate Overload! In between runs, create potions using gathered ingredients, unlock permanent abilities in the lab, and customize your mannequin's gear. Face off against bosses, progress further in Endless mode, or tackle the Daily Challenge. Experiment with new setups, adjust your defenses, and surpass your previous wave record. Each decision can transform a vulnerable defense into a formidable monster-crushing force. Enjoy the game for free directly in your browser on desktop or mobile without any downloads.

How to play

Guard the mannequin in the middle of the arena and ensure its health doesn’t drop to zero as enemies attack. Prior to each wave, choose an unoccupied rune spot to purchase a tower using gold. Select a constructed tower to enhance it. Building and upgrading are only possible during the breaks between waves. Towers will attack on their own. On a desktop, use the mouse to aim and click to hurl a vial. Holding the left mouse button allows for consecutive throws. On mobile, tap the target or hold your finger on the arena. Precise hits inflict additional damage. Between waves, pick upgrade cards and merge elemental effects. Be cautious with cursed cards, as their bonuses may have disadvantages. Once the Overload meter is full, trigger it using the on-screen button or Q. Press Space or the wave button during preparation to initiate the next wave. After every run, invest in permanent talents and concoct potions to ready yourself for the next attempt.
  • HTML5
  • no registration
  • no download
  • endless
  • free
  • browser
  • survival
  • tower defense
  • defense
  • roguelike
  • upgrade
  • monster
  • fantasy

Game info

Age rating
12+
Platforms
Authorization support
Yes
Localization
Russian, English
Screen orientation
Release date
Sep 10, 2026
Cloud saves
Yes
Categories
  1. All games
  2. Arcade
  3. Alchemist's Shop: Rune Defense
Feedback
Games for you
Prison BallPrison Ball
Zuma's Revenge! OriginalZuma's Revenge! Original
Capy linkCapy link
XO TacticsXO Tactics
Pop Bubbles: Find All TreasuresPop Bubbles: Find All Treasures
Monsters & LanternMonsters & Lantern
Cuberra: Build & SurviveCuberra: Build & Survive
Block LabBlock Lab10
Obby: Chicken FarmObby: Chicken Farm
Prism Match 3Prism Match 3
Fruit RoomFruit Room
Echo GardenEcho Garden